Center for Gene Regulation in Health and Disease (GRHD)

Xue-Long Sun

The main research interests in Dr. Sun' group are in the following three areas: 
  • Functional glyco-affinity ligand engineering: For proteomics and glycomics, pathogen and biomarker identification, antiviral drug and targeted drug delivery applications. 
  • Cytomimetic antithrombotics: To explore vascular pathological and surgical interventional sites-local/targeted antithrombotics. 
  • Biological and cellular chemistry: To develop site-specific/chemo- and bio-orthogonal and live cell compatible approaches for biomolecules, biomaterials and cells modification and functionalization.
  • Val Gruzdys
    PhD Student
  • Dr. Rui Jiang
    Post Doctoral Fellow
  • Jaya Kakarla
    MS Student
  • Satya Narla
    PhD Student
  • Poornima Pinnamaneni
    MS Student
  • Pratima Vabbilisetty
    Ph.D. Student
  • Dr. Jacob Weingart
    Post Doctoral Fellow
  • Hailong Zhang
    PhD Student

Peer-Reviewed Publications at Cleveland State University:

2014
84. V.Gruzdys, H. Zhang and Xue-Long Sun*, Glyco-modification of protein with O-cyanate chain-end functionalized glycopolymer via isourea bond formation. 2013, in revision.
83. P. Vabbilisetty and Xue-Long Sun*, Liposome Surface Functionalization Based on Different Anchoring Lipids via Staudinger Ligation, Organic and Biomolecular Chemistry 2014, 12, 1237-1244..
82. S. Narla, P. Pinnamaneni, H. Nie, Y. Li, and Xue-Long Sun*, BSA-boronic acid conjugate as lectin mimetics, Biochemical and Biophysical Research Communications 2014, 443, 562-567.
81. D. Wang, X. Zhou, L. Wang, S. Wang, Xue-Long Sun*, Quantification of free sialic acid in human plasma through a robust quinoxalinone derivatization and LC-MS/MS using isotope-labeled standard calibration, J. Chromatography B 2014, 944, 75-81.
80. R. Jiang, L. Wang, J. Weingart and Xue-Long Sun* Chemo-Enzymatic Bioorthogonal Chemistry for Site-Specific Double Modification of Recombinant Thrombomodulin, ChemBioChem - A European Journal of Chemical Biology, 2014, 15, 42-46.

2013
79. L. Wang, R. Jiang, Xue-Long Sun*, Recombinant Thrombomodulin with Different Domains for Pharmaceutical, Biomedical and Cell Transplantation Applications, Medicinal Research Reviews 2013, in press, DOI: 10.1002/med.21294.
78. J. Weingart, P. Vabbilisetty, Xue-Long Sun*, Membrane mimetic surface functionalization of nanoparticles: Methods and applications. Advances in Colloid and Interface Science 2013 197-198, 68-84.
77. Xue-Long Sun*, Glycosyltransferases as Potential Drug Targets. Medicinal Chemistry  2013, 3, e106.
76. H. Zhang, Jacob J. Weingart, R. Jiang, J. Peng, Q, Wu, Xue-Long Sun*, Syntheses of Bio-Inspired Thrombomodulin Conjugate through Bioorthogonal Chemistry. Bioconjugate Chemistry 2013, 24, 550-559.

2012
75. Xue-Long Sun*, Cellular Glycomics: Strategies and Approaches. Journal of Glycomics and Lipidomics  2012, 2, e105.
74. Y. Ma, I. Sobkiv, V. Gruzdys, H. Zhang and Xue-Long Sun*, Liposomal glyco-microarray for studying glycolipid-protein interactions. Analytical and Bioanalytical Chemistry 2012, 404, 51-58.
73. S. N. Narla and Xue-Long Sun*, Immobilized Sialyloligo-Macroligand and Its Protein Binding Specificity. Biomacromolecules 2012, 13, 1675-1682.
72. H. Nie, Y. Li, Xue-Long Sun*, Recent Advances in Sialic Acid-Focused Glycomics. Journal of Proteomics 2012, 75, 3098-3112.
71. R. Jiang, J. Weingart and Xue-Long Sun* End-Point Immobilization of Recombinant Thrombomodulin via Sortase-Mediated Ligation, Bioconjugate Chem. 2012, 23, 643-649.
70. S. N. Narla, Xue-Long Sun*, Glyco-Macroligand Microarrays with Controlled Glycan Density and Orientation. Lab on Chip, 2012, 12, 1656-1663.  
69. X. Zeng, C. A. S. Andrade, M. D. L. Oliveira, Xue-Long Sun. Carbohydrate-protein interactions and their biosensing applications. Analytical and Bioanalytical Chemistry 2012, 402, 3161-3176.
68. Y. Ma, R. Jiang, H. Zhang and Xue-Long Sun*, Chemoselective Funtionalizable Tethered Bilayer Lipid Membrane for Versatile Membrane Mimetic Systems Fabrication. Journal of Materials Chemistry 2012, 22, 6148-6155.
67. S. N. Narla, H. Nie, Y. Li, Xue-Long Sun*, Recent Advances in Synthesis and Biomedical Applications od Chain-End Functionalized Glycopolymers. J. Carbohydrate Chem. 2012, 32, 67-92.

2011
66. J. Weingart, Xue-Long Sun*, "Glyco-Functionalized Quantum Dots- in ACS Symposium Book Series - Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicines" edited by Xuefei Huang and Joseph Barch, 2011, Volume 1091, Chapter 7, Page 105-121.  
65. Y. Ma, H. Zhang and Xue-Long Sun*, Azide-Reactive Liposome for Chemoselective and Biocompatible Liposomal Surface Functionalization and Glyco-Liposomal Microarray Fabrication, Langmuir 2011, 27, 13097-13103.
64. J. Peng, J. Jiang, W. Wang, X. Qi, Xue-Long Sun, Q. Wu, Glycosylation and Processing of Pro-B-type Natriuretic Peptide in Cardiomyocytes. Biochem. Biophys. Res. Commun. 2011, 411, 593-598.
63. H. Zhang, Y. Ma, Xue-Long Sun*, ¿Chemical Selective and Biocompatible Liposome Surface Functionalization Approach¿ Chapter 16 in Methods in Molecular Biology Book Series: Bioconjugation Protocols, 2nd Ed. Sonny S. Mark Editor (Humana Press/Springer Science), 2011.
62. S. N. Narla, Xue-Long Sun*, Synthesis of Orientated Glyco-Macroligand Based on Site-Specific Immobilization of Chain-End Functionalized Glycopolymer. Organic and Biomolecular Chemistry 2011, 9, 845-850.

2010
61. Y. Ma, H. Zhang and Xue-Long Sun*, Spherical Glycosurface Assembling Based on Chemoselcetive and Biocompatible Immobilization and Further Modification of Intact Liposome. Bioconjugate Chemistry 2010, 21, 1994-1999.
60. Y. Wang, S. Chalagalla, T. Li, Xue-Long Sun, W. Zhao, P. Wang, X. Zeng, Label Free Carbohydrate Biosensors Based on Polyvalent Interaction for Sensitivity Amplification. Biosensors and Bioelectronics 2010, 26, 996-1001.
59. S. Chalagalla, Y. Wang, D. Ray, X. Zeng and Xue-Long Sun*, Synthesis and Characterization of Oriented Glyco-Capturing Macroligand. ChemBioChem 2010, 11, 2018-2025.
58. Xue-Long Sun, Preface for Special Issue of Carbohydrate Recognition and Applications for Medicinal Research Reviews, 2010, 30 (2), 169-170.
57. H. Zhang, Y. Ma, Xue-Long Sun*, Recent Carbohydrate Recognition Based Targeted Drug and Gene Delivery. Medicinal Research Review, 2010, 30, 270-289.
56. S. Chalagalla, Xue-Long Sun*, Synthesis and Characterization of Biotin Chain-End Functionalized Boropolymer as Functional Glyco-Affinity Macroligand, Reactive and Functional Polymers 2010, 70, 471-476.

Before 2009
55. H. Zhang, Y. Ma, Xue-Long Sun*, Chemical Selective Surface Glyco-Functionalization of Liposome through Staudinger Ligation. Chemical Communications, 2009, 3032-3034.
54. Xue-Long Sun, Functional Glyco-Affinity Precipitation for Enhanced Glyco-Proteomics. Current Proteomics, 2008, 5, 202-210.
53. Xue-Long Sun*, L. Yang, and E. L. Chaikof, Chemical Selective Immobilization of Biomolecules through Aqueous Diels-Alder and PEG Chemistry, Tetrahedron Letter, 2008, 49, 2510-2513.
52. C. Stabler, Xue-Long Sun, W. Cui, J. Wilson, C. Haller, and E. L. Chaikof, Surface Re-Engineering of Pancreatic Islets, Bioconjugate Chemistry 2007, 18, 1713-1715.
51. Xue-Long Sun, Recent Multivalent Sialyloligosaccharide and Sialylmimetics-Based Antiinfluenza Strategies. Current Medicinal Chemistry 2007, 14, 2304-2313.  

Peer-Reviewed Publications at Emory University:
50. J. T. Wilson, W. Cui, Xue-Long Sun, C. T. Tucker-Burden, C. J. Weber, E. L. Chaikof, In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film. Biomaterials 2007, 28, 609-617.
49. S. W. Jordan, K. M. Faucher, J. Caves, R. A. Apkarian, S. M. Rele, Xue-Long Sun, S. R. Hanson E. L. Chaikof, Fabrication of a self-assembled membrane-mimetic thin film on a PTFE vascular graft surface. Biomaterials 2006, 27, 3473-3481.
48. Xue-Long Sun*, N. Biswas, T. Kai, K. Z. Dai, R. A. Dluhy, and Elliot L. Chaikof, Synthesis and Self-Assemblies of Asymmetric Lipid Bolaamphiphile, Langmuir 2006, 22, 1201-1208.
47. P. Tseng, S. W. Jordan, Xue-Long Sun, E. L.Chaikof, Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model. Biomaterials 2006, 27, 2768-2775.
46. P. Tseng, S. M. Rele, Xue-Long Sun, E. L. Chaikof, Fabrication and characterization of heparin functionalized membrane-mimetic assemblies. Biomaterials 2006, 27, 2627-2636.
45. P. Tseng, S. M. Rele, Xue-Long Sun, E. L. Chaikof, Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor induced thrombin generation in a flow model. Biomaterials 2006, 27, 2637-2650.
44. E. L. Chaikof, P. Tseng, S.M. Rele, S.W. Jordan and Xue-Long Sun, Surface bound thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model. J. Surg. Res. 2006, 130, 203-204.
43. Xue-Long Sun*, C. Stabler, C. Cazalis, E. L. Chaikof, Carbohydrates and Protein Immobilization onto Solid Surface by Sequential Diels-Alder and Azide-Alkyne Cycloaddition, Bioconjugate Chem. 2006, 17, 52-57.
42. Xue-Long Sun*, C. Haller, X. Wu, and Elliot L. Chaikof, One-Pot Glyco-Affinity Precipitation Purification: The Flexible Alignment of Solution-Phase Capture/Release and Solid-Phase Separation. J. Proteome Res. 2005, 4, 2355-2359.
41. T. Kai, Xue-Long Sun*, K. M. Faucher, and Elliot L. Chaikof, Design and Synthesis of Asymmetric Acyclic Phospholipid Bolaamphiphiles, J. Org. Chem. 2005, 70, 2606-2615.
40. Xue-Long Sun, ChemMedChem (European Jorunal of Medicinal Chemistry, Wiley Interscience), 2005, 1, 159. Book Review: ¿Biopolymers for Medical and Pharmaceutical Applications¿. Ed. Alexander Steinbüchel and Robert H. Marchessault, 1145pp, ISBN 3527311548, Wiely-VCH, 2005.
39. M. Murphy, K. M. Faucher, Xue-Long Sun, E. L. Chaikof and R. A. Dluhy, Analysis of photoinitiated polymerization in a membrane mimetic film using infrared spectroscopy and near-IR Raman microscopy. Colloids and Surface B: Biointerface 2005, 46, 226-232.
38. R. Guan, Xue-Long Sun, D. Grande, S. Baskaran, and E. L. Chaikof, A Glycopolymer Chaperone for Fibroblast Growth Factor-2, Bioconjugate Chem. 2004, 15, 145-151.
37. C.-M. Dong, Xue-Long Sun, K. M. Faucher, R. P. Apkarian, and Elliot L. Chaikof, Design, Synthesis and Characterization of Glycopolymer-Polypeptide Triblock Copolymers, Biomacromolecules, 2004, 5, 224-231.
36. Xue-Long Sun*, W. Cui, T. Kai, and E. L. Chaikof, A Facile Synthesis of Bifunctional Phospholipids for Biomimetic Membrane Engineering, Tetrahedron 2004, 60, 11765-11770.
35. Xue-Long Sun*, W. Cui, C. Haller, and E. L. Chaikof, Site-Specific Multivalent Carbohydrate-Labeled Quantum Dots and Magnetic Beads, ChemBioChem 2004, 5, 1593-1596.
34. S. Hou, Xue-Long Sun*, C.-H. Dong, and E. L. Chaikof, Facile Synthesis of Chain-End Functionalized Glycopolymers for Site-Specific Bioconjugation, Bioconjugate Chem. 2004, 15, 954-959.
33. K. Faucher, Xue-Long Sun, and E. L. Chaikof, Fabrication and Characterization of Glycocalyx-Mimetic Surface, Langmuir 2003, 19. 1664-1670.
32. Xue-Long Sun,* K. M. Faucher, M. Houston, D. Grande, and E. L. Chaikof, Design and Synthesis of Biotin-Terminated Glycopolymer for Surface Glycoengineering, J. Am. Chem. Soc. 2002, 124, 7258-7259.
31. Xue-Long Sun, D. Grande, S. Baskaran, and E. L. Chaikof, Glycosaminoglycan-Mimetic Biomaterials 4: Synthesis of Sulfated Lactose-Based Glycopolymers that Exhibit Anticoagulant Activity, Biomacromolecules 2002, 3, 1065-1070.
30. J. Feng, P. Y. Tseng, K. M. Faucher, J. M. Orban, Xue-Long Sun, and E. L. Chaikof, Functional Reconstitution of Thromobomodulin with a Substrated Membrane-Mimetic Polymer Film, Langmuir 2002, 18, 9907-9913.
29. Xue-Long Sun, Keith M. Faucher and Elliot L. Chaikof, ¿Cytomimetic Biomaterials: Fabrication, Characterization and Applications¿ in ¿Biomimetic Materials and Design: Interactive Biointerfacial Strategies, Tissue Engineering, and Target Drug Delivery¿. Chapter 5, pp139-157, Dillow, A. K. and Lowman, A. Eds. Marcel-Dekker, Inc. Publisher. August 2002.
28. S. Baskaran, D. Grande, Xue-Long Sun, A, Yayon, and E. L. Chaikof, Glycosaminoglycan-Mimetic Biomaterials 3: Glycopolymers Prepared from Alkene-Derivatized Mono- and Disaccharide-Based Glycomonomers, Bioconjugate Chem. 2002, 13, 1309-1313.
27. H. Liu, K. M. Faucher, Xue-Long Sun, J. Feng, J. M. Orban, and E. L. Chaikof, A Supported Lipid Bilayer as a Membrane-Mimetic Cell Encapsulation Barrier, Langmuir 2002, 18,1332-1339.
26. Xue-Long Sun, H. Liu, J. M. Orban, L. Sun, and E. L. Chaikof, Synthesis and Terminal Functionalization of Polymerizable Phosphatidyl ethanolamine, Bioconjugate Chem. 2001, 12, 673-677.

Peer-Reviewed Publications at Riken Institute:
25. H. Hinou, Xue-Long Sun, and Y. Ito, Systematic Synthesis and Inhibitory Activity of Bisubstrate-Type Inhibitors of Sialyltransferases, J. Org. Chem. 2003, 68, 5602-5613.
24. H. Hinou, Xue-Long Sun, and Y. Ito, Bisubstrate-Type Inhibitors of Sialyltransferase, Tetrahedron. Lett. 2002, 43. 9147-9150.
23. C.-T. Guo, Xue-Long Sun, O. Kanie, K. F. Shotridge, T. Suzuki, D. Miyamoto, K. I.-P. Hidari, C.-H. Wong, and Y. Suzuki, A Discovery of An O-Glycoside of Sialic Acid Derivative That Inhibits both Hemagglutinin and Sialidase of Human Influenza Virus, Glycobiology 2002, 12, 183-190.
22. Xue-Long Sun, Y. Kanie, C.-T. Guo, O. Kanie, Y. Suzuki, and C.-H. Wong, Syntheses of C-3 Modified Sialylglycosides as Inhibitors of Influenza Hemagglutinin and Neuraminidase, Eur. J. Org. Chem. 2000, 14, 2643-2653.
21. Xue-Long Sun, Pharmacia (Journal of the Pharmaceutical Society of Japan), 1999, 35, 1165-1166. Article Review: K. Oshima, Y. Aoyama, Regiospecific Glycosidation of Unprotected Sugars via Arylboronic Activation. J. Am. Chem. Soc. 1999, 121, 2315-2316.

Peer-Reviewed Publications at Kitasato University:
20. Xue-Long Sun, N. Sato, T. Kai, and K. Furuhata, Novel Practical Synthesis of 2,6-Anhydro-3- eoxy-D-glycero-D-galacto-non-2-enoic Acids (KDN2en) and Its C-4 Nitrogen-modifying Derivatives. Carbohydr. Res. 2000, 323, 1-6.
19. Xue-Long Sun, T. Kai, H. Takayanagi, and K. Furuhata, A Straightforward Synthesis of ¿-Furyl Amide via Lewis Acid-mediated Allylic Substitution. SYNLETT 1999, (9), 1399-1341.
18. Xue-Long Sun, T. Kai, N. Sato, H. Takayanagi, and K. Furuhata, Synthesis of 4-Oxo- and 4-Hydroxyimino-KDN2en Derivatives. J. Carbohydr. Chem. 1999, 18, 1131-1138.
17. Xue-Long Sun, T. Kai, H. Takayanagi, and K. Furuhata, Synthesis of Sialic Acid Analogs with the Acylamino Groups at C-4 (N-Acyl Regioisomers of Sialic Acids). Carbohydr. Res. 1997, 298, 181-189.
16. Xue-Long Sun, T. Kai, M. Tanaka, H. Takayanagi, and K. Furuhata, Synthesis of 2,6-Anhydro-3-deoxy-D-glycero-D-galacto-non-2-enoic Acids (KDN2en) and its Hydrogenation Products. J. Carbohydr. Chem. 1997, 16, 541-547.
15. T. Kai, Xue-Long Sun, H. Takayanagi, and K. Furuhata, Oxidation Products of C-4 and C-7 Hydroxyls into the Methyl ¿-Glycoside Derivatives of KDN. J. Carbohydr. Chem. 1997, 16, 533-540.
14. T. Kai, Xue-Long Sun, Takayanagi, and K. Furuhata, Synthesis of Sialic Acid Analogs with the Oxime Groups at C-4 or C-5 of KDN. J. Carbohydr. Chem. 1997, 16, 521-532.
13. Xue-Long Sun, T. Kai, M. Takayanagi, and K. Furuhata, A Novel Glycosylation of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acids. Chem. Pharm. Bull. 1996, 45, 795-798.
12. Xue-Long Sun, H. Takayanagi, K. Matsuzaki, H. Tanaka, K.Furuhata, and S. Omura, Synthesis and Inhibitory Activities of Isochromophilone Analogues against gp120-CD4 binding. J. Antibiotics, 1996, 49, 689-692.
11. T. Kai, Xue-Long Sun, M. Tanaka, H. Takayanagi, and K. Furuhata, Reaction products from Fisher's Methylation of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN). Chem. Pharm. Bull. 1996, 44, 208-211.
10. M. Tanaka, T. Kai, Xue-Long Sun, H. Takayanagi, and K. Furuhata, Synthesis of N-Glycosyl-8-O-Sulfoneuraminic Acid. Chem. Pharm. Bull. 1995, 43, 2095-2098.
9. M. Tanaka, T. Kai, Xue-Long Sun, H. Takayanagi, and K. Furuhata, Synthesis of Fluorescent 4-Methyl-7-Thiocoumaryl S-Glycosides of Sialic Acid. Chem. Pharm. Bull. 1995, 43, 1844-1848.
8. Xue-Long Sun, T, Kai, M. Tanaka, H. Takayanagi, K. and Furuhata, A Facile Synthesis of 4-Acylamino-2,6-anhydro-2,3,4-trideoxy-D-glycero-D-galacto-non-2-enoic Acids. Chem. Pharm. Bull. 1995, 43, 1654-1658.
7. S-S, Li, Xue-Long Sun, H. Ogura, Y. Konda, T. Sasaki, Y. Toda, H. Takayanagi, and Y. Harigaya, Photocycloaddition of Benzoylated 2'-Deoxyribo-nucleoside to 2,3-Dimethyl-2-butene. Chem. Pharm. Bull. 1995, 43, 144-146.
6. Y. Konda, T. Sasaki, Xue-Long Sun, X. Li, M. Onda, H. Takayanagi, and Y. Harigaya, Conformational Analysis of C3'-C8 Connected Biflavones. J. Heterocyclic Chem. 1995, 32, 1531-1535.
5. Xue-Long Sun, N. Haga, H. Ogura, and H. Takayanagi, Synthesis of ¿-N-Glycoside of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN) using Nucleobase and Their Photocycloaddition to 2,3-Dimethyl-2-butene. Chem. Pharm. Bull. 1994, 42, 2352-2356.
4. Y. Konda, T. Sasaki, Xue-Long Sun, X. Li, M. Onda, H. Takayanagi, and Y. Harigaya, Absolute Structure of 2'-Desacetoxyaustrospicatine Established by X-Ray Analysis and Circular Dichroism Spectroscopy. Chem. Pharm. Bull. 1994, 42, 2621-2624.

Peer-Reviewed Publications at Shenyang Pharmaceutical University:
3. Xue-Long Sun, L. -J. Wu, X. Li, Y. Konda, and M. Onda, Chemical Studies of Tuxus cuspidata Sieb et Zucc. Chin. J. Med. Chem., 1992, 2, 31-34.
2. Xue-Long Sun and X. Li, Recent Chemical Studies on Pine Leaf Components. J. ShenYang. Pharm. Univ, 1991, 8, 145-149.
1. Y. Harigaya, Y. Konda, M. Iguchi, M. Onda, X. Li, L. J. Wu, S. S. Li, and Xue-Long Sun, Spectroscopic Studies of Brusatol J. Nat. Prod. 1989, 52, 740-748