Center for Gene Regulation in Health and Disease (GRHD)

Andrew Resnick

My research activity has two main tracks: the role of sensory cilia in cellular mechanosensation and optical probes of matter.  Experimental tools we use include epithelial cell culture and electrophysiology, microscopy and laser tweezers, microfluidics and analytical modeling. Biological systems under investigation include renal and airway epithelial tissue to study the connection between fluid flow stimulation and physiological responses in the context of tissue maintenance and repair.  The nature of our work is highly multidisciplinary, reflecting an idea I believe to be true- important research of the future will be multidisciplinary, and if our results are to contribute meaningfully at the forefront of knowledge, we must be able to cross bridges between disciplines. One of our long term research goals is to bridge the gap between Physics and Biology in the hope that revolutionary new results will be produced.  
  • student
    Justin Flaherty
    Undergraduate Student
  • student
    Muhammad Tayeh
    Undergraduate Student
  • student
    Subhra Nag
    Graduate Student
  • student
    Tara Diba
    Graduate Student
  • student
    Vikram Seetharaman
    Graduate Student
Resnick A. (2015) Mechanical Properties of a Primary Cilium As Measured by Resonant Oscillation. Biophys. J. 109, 1-8
Lofgren, I and Resnick, A. (2015) A Simplified Model for the Optical Force exerted on a Vertically Oriented Cilium by an Optical Trap and the Resulting Deformation. Photonics 2, 604-618; doi:10.3390/photonics2020604 (invited paper).
Glaser, J., Hoeprich, D. and Resnick A. (2014) Near real-time measurement of forces applied by an optical trap to a rigid cylindrical object. Opt. Eng., 53 (7), 074110 doi:10.1117/1.OE.53.7.074110.
Boslett, B., Nag, S. and Resnick, A. (2014) Detection and Antibiotic Treatment of Mycoplasma arginini Contamination in a Mouse Epithelial cell line Restores Normal Cell Physiology. BioMed Research International 2014, 532105.
Resnick A. (2011) Chronic Fluid Flow is an Environmental Modifier of Renal Epithelial Function.  PLoS ONE  6(10): e27058. 
Resnick A. (2010) Use of optical tweezers to probe epithelial mechanosensation.  J. Biomedical Optics 15 (1), 015005, 1-8.
Yu Cheng, Anna C. Samia,  Jun Li, Ping Zhang, Malcolm E. Kenney, Andy Resnick,Clemens Burda (2010) Quantification the Release of a Gold Nanoparticle-Caged PDT Drug Pc 4 into Human Cancer Cells. Langmuir 26 (4), 2248-2255 (featured article).
Resnick A, Hopfer U. (2008) Mechanical stimulation of primary cilia. Frontiers in Bioscience, 13, 1665-1680.
Resnick A, Hopfer U. (2007) Force-response considerations in ciliary mechanosensation. Biophys J. 93 (4), 1380-1390.
Resnick A (2003) Use of laser tweezers for colloid science. J. Colloid and Interface Science 262, 55-59.
Resnick A. (2002) Differential interference contrast microscopy as a polarimetric instrument. Applied Optics 41, 38-45.
Resnick A. (2001) Design and Construction of a space-borne optical tweezer apparatus. Review of Scientific Instruments 72, 4059-4065.
Resnick A, Persons C., and Lindquist G. (1999) Polarized Emissivity and Kirchhoff’s Law. Applied Optics 38, 1384-1387.
Watson J., Wellfare M., Foster J., Owens M., Vechinski D., Richards M., and Resnick A. (1998) Irma Multisensor Predictive Signature Model. Proc. SPIE Vol. 3375, p. 78-92, Targets and Backgrounds: Characterization and Representation IV, Wendell R. Watkins; Dieter Clement; Eds.
Resnick A and Alexander J.I.D., (1997) A Coherent Fourier Optical Imaging System for Liquid Bridge Research. Proc. SPIE Aerosense 1997 meeting, Vol 3073.
Resnick A. and Alexander J.I.D. (1997) A Plateau tank apparatus for liquid bridge research. Review of Scientific Instruments 68 (3), 1495-1500.
Slobozhanin L., Alexander J.I.D., and Resnick A. (1997) Bifurcation of the equilibrium states of a weightless liquid bridge. Phys. Fluids 9 (7), 1893-1905.
Alexander, J. I. D., Delafontaine, S., Resnick A. and Carter, W. C. (1996) Stability of Non-axisymmetric Liquid Bridges. Microgravity Sci. Technol. IX/3, 193-200.