Chemistry

Affiliated Faculty Information

I. Affiliated Faculty, Lerner Research Institute, Cleveland Clinic

 Ashok Agarwal, Ph.D.    https://www.clevelandclinic.org/reproductiveresearchcenter/staff/agarwala.html  Biological markers of oxidative stress; proteomic  and bioinformatics in DNA damage, apoptosis and preserving fertility in patients with cancer; laboratory and clinical studies assessing efficacy of certain antioxidants in improving male fertility

Alex Almassan, Ph.D. http://www.lerner.ccf.org/cancerbio/almasan/  Autophagy; apoptosis; cell cycle; DNA damage; ubiquitin; DNA repair; cancer therapeutics; radiation therapy; leukemia; epithelial tumors; prostate cancer

Suneel Apte, M.B.B.S, Ph.D.  https://www.lerner.ccf.org/bme/apte/  Extracellular matrix; proteolysis; metalloproteinases; ADAMTS proteases; ADAMTS-like proteins; proteomics; morphogenesis; cardiovascular; musculoskeletal; birth defects; fetal-maternal medicine; eye disorders; neural tube; craniofacial development; smooth muscle; post-translational modification; inherited connective tissue disorders; osteoarthritis; primary cilium

Mark Aronica, M.D. https://www.lerner.ccf.org/immuno/aronica/  Mechanisms by which specific ECM proteins contribute to the onset of asthma

Kathleen Berkner, Ph.D. http://www.lerner.ccf.org/moleccard/berkner/  Vitamin K; vitamin K-dependent protein carboxylation; hemostasis; anticoagulation; calcification; vitamin K-dependent clotting factors deficiency (VKCFD); pseudoxanthoma elasticum; warfarin resistance; gamma-glutamyl carboxylase; vitamin K oxidoreductase (VKOR)

Mark Brown, Ph.D.  http://www.lerner.ccf.org/cms/brown/  Lipid metabolism; lipoprotein metabolism; atherosclerosis; obesity; diabetes; reverse cholesterol transport; triacylglycerol; nutrition

Tatiana Byzova, Ph.D.  https://www.lerner.ccf.org/neurosci/byzova/  Angiogenesis; endothelial cells; integrins; extracellular matrix; cell adhesion; tumor progression; vascular biology; signal transduction in endothelium and platelets; oxidative stress and vasculature; toll-like receptors in angiogenesis

John Crabb, Ph.D.  http://www.lerner.ccf.org/eye/crabb/  Eye; age-related macular degeneration; glaucoma; uveal melanoma; proteomics

Donna Driscoll, Ph.D.  http://www.lerner.ccf.org/cellbio/driscoll/  RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium

Serpil Erzurum, M.D.  https://www.lerner.ccf.org/immuno/erzurum/  Asthma; pulmonary vascular disease; hypoxia; metabolism

Paul Fox, Ph.D.  http://www.lerner.ccf.org/cellbio/fox/  Angiogenesis; atherosclerosis; cell migration; endothelial cells; iron metabolism; macrophages; translational control

Vincent Hascall, Ph.D.  https://www.lerner.ccf.org/bme/hascall/  Hyaluronan in inflammation; asthma; diabetes; autophagy; hyperglycemia; connective tissue biology

Stanley Hazen, M.D., Ph.D.  http://www.lerner.ccf.org/cellbio/hazen/  Inflammation; atherosclerosis; asthma; myeloperoxidase; cardiovascular diseases; HDL; peroxidases; airway remodeling; intestinal microbiota; gut flora; cardiometabolic disease

Christopher Hine, Ph.D.  https://www.lerner.ccf.org/cms/hine/  Dietary restriction; aging; lifespan extension; stress resistance; exercise; hydrogen sulfide (H2S) production and metabolism; sulfur amino acid metabolism; endocrine signaling and longevity

Sadashiva Karnik, Ph.D.  http://www.lerner.ccf.org/cms/karnik/  GPCRs; angiotensin receptors; ARBs; biased signaling; cardiac hypertrophy; hypertension; heart failure; structure-function of GPCRs; transmembrane signaling; microRNA; gene expression; chromatin protein modifications; STAT3 and U-STAT3 signaling; RGS proteins

Xiaoxia Li, Ph.D.  https://www.lerner.ccf.org/immuno/li/  Signal transduction in innate and adaptive immunity

Daniel Lindner, M.D., Ph.D.  https://my.clevelandclinic.org/staff/3044-daniel-lindner  Mechanisms of acquired drug resistance in renal cancer, development of more effective drugs to treat myelodysplastic syndrome and acute myelogenous leukemia

Thomas McIntyre, Ph.D.  http://www.lerner.ccf.org/cellbio/mcintyre/  Lipid mediators; inflammatory signaling; platelet biology; biochemistry; acute kidney injury

Richard Padgett, Ph.D.  http://www.lerner.ccf.org/cms/padgett/  Transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry

Edward Plow, Ph.D.  http://www.lerner.ccf.org/moleccard/plow/  Integrins; plasminogen; kindlins; thrombospondins; atherothrombosis

Eugene Podrez, M.D., Ph.D.  http://www.lerner.ccf.org/cms/podrez/  Atherosclerosis; thrombosis; atherothrombosis; platelets; macrophage; scavenger receptors; LDL; HDL; cholesterol; phospholipids; oxidative stress; lipid peroxidation

Jun Qin, Ph.D.  http://www.lerner.ccf.org/moleccard/qin/  Signal transduction; integrin; cell adhesion; cell migration; kinase; heart disease; cancer; structural biology; protein NMR; protein crystallography

Sujata Rao, Ph.D.  https://www.lerner.ccf.org/eye/rao/  Eye; developmental biology; circadian clock; neurovascular development; thyroid hormone signaling; cone photoreceptors; vascular remodeling

Nima Sharifi, M.D.  https://www.lerner.ccf.org/cancerbio/sharifi/  Prostate cancer; androgens; metabolism; steroids; castration-resistant prostate cancer; androgen receptor; hormone therapy; medical oncology; dihydrotestosterone; enzymes; biochemistry

Robert Silverman, Ph.D.  http://www.lerner.ccf.org/cancerbio/silverman/  Interferon; rnase l; antiviral innate immunity; oncolytic virotherapy, DNA methyltransferase inhibitor

Jonathan Smith, Ph.D.  http://www.lerner.ccf.org/cellbio/smith/  Atherosclerosis; HDL metabolism; atrial fibrillation; genetics; genomics; eQTL; gene expression; reverse cholesterol transport; dysfunctional HDL; RNAseq; allelic expression imbalance; ABCA1; mouse models; zinc finger nuclease

George Stark, Ph.D.  https://www.lerner.ccf.org/cancerbio/stark/  Interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock

Dennis Stuehr, Ph.D.  http://www.lerner.ccf.org/immuno/stuehr/  Inflammation; nitric oxide; heme transport; soluble guanylate cyclase; electron transfer

Wai Hong Wilson Tang, M.D. http://www.lerner.ccf.org/cms/tang/  Heart failure; cardiomyopathy; nitrative stress; metabolomics; cardio-renal syndrome

Bruce Trapp, Ph.D.  http://www.lerner.ccf.org/neurosci/trapp/  Multiple sclerosis; glia; oligodendrocytes; astrocytes; neuroprotection; myelin, autism

Qing Wang, Ph.D.  http://www.lerner.ccf.org/moleccard/wang/  Cardiac arrhythmias and sudden death (VT, VF, AF); coronary artery disease (CAD) and myocardial infarction (MI); pulmonary arterial hypertension (PAH); vascular biology; genetics; genome-wide association studies (GWAS); next generation sequencing; genome editing; gene therapy

Qingyu Wu, M.D., Ph.D.  http://www.lerner.ccf.org/cms/wu/ Blood pressure; cardiac function; cardiovascular disease; cell membrane proteases; corin; hormone processing; hypertension; preeclampsia; pregnancy-induced hypertension; proteolytic enzymes; vascular biology 

Bin Zhang, Ph.D.  https://www.lerner.ccf.org/gmi/zhang/  Mechanism of intracellular trafficking in human disease development; protein secretion; endoplasmic reticulum stress; hemophilia; alpha-1-antitrypsin deficiency, cardiovascular diseases; cancer

II. Affiliated Faculty, Doctoral Clinical Laboratory Scientists             

A. Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic    

https://my.clevelandclinic.org/departments/pathology

Edmund Z. Reineks, M.D., Ph.D., DABCC  https://my.clevelandclinic.org/staff/15151-edmunds-reineks   Point of care testing; quality; lab directorship; special topics

Adam McShane, Ph.D., DABCC  https://my.clevelandclinic.org/staff/22478-adam-mcshane  Automated chemistry; cardiovascular disease; blood gases

Marvin Natowicz, M.D., Ph.D.  https://my.clevelandclinic.org/staff/4098-marvin-natowicz   Biochemical genetics; metabolic diseases

Xiaochun (Susan) Zhang, M.D., PhD, DABCC, DABMLI  Immunology; CRO

Thomas Daly, M.D.   https://my.clevelandclinic.org/staff/98539-thomas-daly  Laboratory operations and finance

Manjula Gupta, Ph.D.   https://my.clevelandclinic.org/staff/823-manjula-gupta  Cancer; endocrinology

Jessica Colon-Franco, Ph.D., DABCC   https://my.clevelandclinic.org/staff/24086-jessica-colon-franco  Endocrinology; special chemistry; leadership

Kamran Kadkhoda, Ph.D., DABMLI    https://my.clevelandclinic.org/staff/24007-kamran-kadkhoda  Immunopathology; serology; allergy; cellular immunology

B. Department  of Pathology, MetroHealth Medical Center

https://www.metrohealth.org/pathology

Michael Ip, Ph.D., DABCC   Clinical chemistry; endocrinology; prenatal diagnosis; infertility; POCT; clinical toxicology; critical care lab; rapid response labs

C. Department of Pathology and Laboratory Medicine, Children’s Hospital Medical center of akron

https://www.akronchildrens.org/locations/Pathology-and-Laboratory-Medicine.html

Sihe Wang, Ph.D., DABCC   https://www.akronchildrens.org/people/Sihe-Wang.html  General clinical chemistry; pediatric testing; chromatography; mass spectrometry; assay development; CLIA regulation; laboratory management; process improvement

D. Quest Diagnostics Cleveland HeartLab Center of Excellence

http://www.clevelandheartlab.com/

Deborah Sun, Ph.D.   Clinical laboratory operations and management

III. Affiliated Faculty Case Western Reserve University or MetroHealth/Case Western Reserve University

(*Faculty with primary position at MetroHealth Medical Center) 

Romani Andrea M.D., Ph.D.  https://physiology.case.edu/person/andrea-romani/   Regulation of magnesium homeostasis and transport in mammalian cells

Ge Jin, Ph.D.  https://case.edu/dental/node/2466   Mechanism of cancer cell-derived cytokines and/or metabolites; immune response and role of HIV-infection in development/progression of non-AIDS-defining cancers

*Jeffrey Schelling, M.D. (MetroHealth Medical Center/Case Western Reserve University)  https://physiology.case.edu/people/visitor/jeffrey-r-schelling/  Mechanisms of chronic kidney disease progression; in vitro molecular and cellular methods, animal models and human studies investigating glomerular and tubulointerstitial pathophysiology

*Bing-Cheng Wang, Ph.D.  (MetroHealth Medical Center/Case Western Reserve University) https://case.edu/medicine/pharmacology/people/bingcheng-wang  Roles of Eph receptor tyrosine kinases in invasive growth and distal metastasis of cancer cells

Wen-Quan Zou, M.D., Ph.D.  https://case.edu/medicine/pathology/faculty/wen-quan-zou   Protein aggregation in the conformational diseases; pathologic prion proteins (PrPC and PrPSc) in prion diseases (PrD); neurotoxic amyloid β (Aβ) in Alzheimer disease (AD); Creutzfeldt-Jakob disease (CJD)

IV. Affiliated Faculty, Cleveland State University

Jerry Mundell, Ph.D.    Manager, Freshman Chemistry Program, Department of Chemistry

V. Affiliated Faculty, NASA

James L. Smialek Ph.D.   https://re.grc.nasa.gov/people/senior-technologists/  High temperature oxidation; coatings