Center for Gene Regulation in Health and Disease (GRHD)

Jackson Taylor

My research focuses on the interplay between epigenetic alterations and aging. Some of the questions my research broadly seeks to address include: (i) how does the epigenome change during aging and age-related disease? (ii) What are the consequences of these changes on gene expression, cellular function, and longevity? (iii) Can modifying the epigenome be used as a strategy for the treatment of age-related disease? Answering these questions will provide a better understanding of the biology of aging and has application for the treatment of agerelated
diseases.

Taylor JR, Wood JW, Chang CC, Mizerak EM, Finn M, Liu JL, Hinthorne SL, Gordon S, Hutfilz CR, Klein MA, Denu JM, Gorbunova V, Boeke JD, Sedivy JM, Helfand SL. (2022) Sirt6 regulates lifespan in Drosophila melanogaster. PNAS, 119 (5): e2111176119.

Gorbunova V, Seluanov A, Mita P, Boeke JD, Linker S, Gage FH, Kreiling JA, Petrashen AP, Taylor JR, Helfand SL, Sedivy JM. (2021) The involvement of transposable elements in aging and ageassociated diseases. Nature, 596 (7870): 43-53.

Taylor JR, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu Y. (2017) Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice. Immunity & Ageing, 14: 15.

Pereyra AS, Mykhaylyk O, Lockhart EF, Taylor JR, Delbono O, Goya RG, Plank C, Hereñu CB. (2016) Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells. J Nanomed Nanotechnol., 7: 2.

Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR Jr, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG, Kaufman JD, Post WS, Hoeschele I, Herrington DM, Bell DA, Liu Y. (2015) DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations with Cigarette Smoking and Subclinical Atherosclerosis. Circ Cardiovasc Genet., 5: 707-716.

Zhang T, Taylor JR, Pereyra AS, Messi ML, Wang ZM, Hereñú C, and Delbono O. (2015) Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle. Exp Cell Res., 336(2): 276-286.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo S, de la Fuente A, Liu TF, Johnson C, Barr G, Register TC, Donohue KM, Talor M, Cihakova D, Gu C, Divers J, Kuo J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr., Kritchevsky SB, Hoeschele I, McCall CE, Herrington D, Tracy RP, Liu Y. (2015) Transcriptomic profiles of aging in purified human immune cells. BMC Genomics, 16: 333.

Reynolds LM*, Taylor JR*, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr., Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington D, Tracy RP, Liu Y. (2014) Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nature Commun., 5: 5366. *co-first authors.

Taylor JR, Zhang T, Messi ML, Wang ZM, Hereñú C, Kuan PF, Delbono O. (2014) The Cavβ1a Subunit Regulates Gene Expression and Suppresses Myogenin in Muscle Progenitor Cells. J Cell Biol., 205(6): 829-846.

Taylor JR, Delbono O. (2012) Sarcopenia should be defined as an age-related condition based on clinical but not cellular features.
Commentaries on Viewpoint: Muscle atrophy is not always sarcopenia. J Appl Physiol., 113(4): 680-684.

Zhang T, Birbrair A, Wang ZM, Taylor JR, Messi ML, Delbono O. (2013) Troponin T nuclear localization and its role in aging skeletal muscle. Age (Dordr)., 35(2): 353-370.

Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Steelman LS, McCubrey JA. (2011) Cooperative effects of akt-1 and raf-1 on the induction of cellular senescence in Doxorubicin or tamoxifen treated breast cancer cells. Oncotarget, 2(8): 610-626.

Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. (2009) Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell, 8(5): 584-594. 

Steelman LS, Navolanic PN, Sokolosky M, Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Wong EW, Stadelman K, Terrian DM, Leslie N, Martelli AM, Stivala F, Libra M, Franklin RA, McCubrey JA. (2008) Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity of mTOR inhibitors. Oncogene, 27(29): 4086-4095.

McCubrey JA, Sokolosky ML, Lehmann BD, Taylor JR, Navolanic PM, Chappell WH, Abrams SL, Stadelman KM, Wong EW, Misaghian N, Horn S, Bäsecke J, Libra M, Stivala F, Ligresti G, Tafuri A, Milella M, Zarzycki M, Dzugaj A, Chiarini F, Evangelisti C, Martelli AM, Terrian DM, Franklin RA, Steelman LS. (2008) Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Adv Enzyme Regul., 48: 113-135.