Center for Gene Regulation in Health and Disease (GRHD)

Research News

Jun. 15, 2013:
Two Ph.D. students of GRHD member Dr. Michael Kalafatis presented their recent discoveries on the blood coagulation Factor V in major national and international conferences. Joesph R. Wiencek has been selected by the American Association for Clinical Chemistry for the highly competitive $2,500 travel award to attend the 2013 AACC Annual Meeting in Houston, TX. Joe's work has also been selected for an oral presentation at the XXIV Congress of the International Society on Thrombosis and Haemostasis, in Amsterdam, the Netherlands from June 29 to July 4, 2013. Joe has also another eposter presentation at the same meeting. Mahesheema Na, another PhD student in Dr. Kalafatis' group, is also presenting two studies in the same meeting: one oral presentation and an eposter. These studies offer important insights into the function of Factor V, deficiency in which leads to predisposition for hemorrhage, while some mutations (notably, Factor V Leiden) predispose for thrombosis. Our congratulations to Joe, Sheema and Prof. Kalafatis.

Jun. 3, 2013:
Sujata Jha, a PhD student of Dr. Anton Komar, has been selected for oral presentation of her research at the EMBO conference, 'The Biology of Molecular Chaperones', 17 – 22 May 2013, Santa Margherita di Pula, Italy. Our congratulations to Sujata, and to Dr. Komar! The Conference home page is here:

May 29, 2013:
Congratulations to GRHD member Dr. Anton Komar for winning a 2-year American Heart Association Grant-in-Aid award on "Comparative study of nonsynonymous and synonymous mutations causing hemophilia B".
Dr. Komar is a renowned expert in multiple aspects of translational regulation, including co-translational protein folding and single nucleotide polymorphisms (SNP).

Jan. 2013:
Congratulations to GRHD member Dr. Bin Su for receiving an NIH AREA award (R15) titled "Drug development of orally active anti-trypanosomiasis agents".
Dr. Su is a medicinal chemist focusing on anti-cancer and anti-parasite drug development. African trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease caused by Trypanosoma brucei. It threatens over 60 million people in 36 countries of sub-Saharan Africa. There are no effective vaccines and satisfactory drugs for its treatment. Dr. Su and T. Brucei biologist Dr. Bibo Li will work together to develop new small molecule drugs to treat this neglected disease.

Nov. 2012:
Congratulations to GRHD members for recently receiving a Federal grant (NIH/NCRR) titled "Nikon A1RSI Confocal Microscope" (PI: Dr. Sailen Barik; Major Users: Drs. Bibo Li, Barsanjit Mazumder, Xue-Long Sun, Roman Kondratov).
This high-power microscope, capable of capturing still and video images in fully programmed mode, will allow studies of cellular structures and their behavior in great detail and clarity.

Sep. 23, 2011:
Dr. Roman Kondratov's funding success and his breakthrough research have been featured in Crain's Cleveland Business
The Cleveland State researcher won a $1.5 million grant to study the aging process. Dr. Kondratov will examine the effects of circadian clocks on aging under dietary restriction. Circadian rhythms are 24-hour internal cycles found in many living organisms. Read more »

Sep. 19, 2011:
Congratulations to GRHD member Dr. Valentin Boerner for winning a three-year R15 Federal grant (NIH) to study "Control of pairing and recombination during meiosis".
Dr. Boerner is an expert in the mechanism of chromosome segregation during gamete formation, a key factor for reproductive health in humans.

Sep. 15, 2011:
Congratulations to GRHD member Dr. Roman Kondratov for winning a $1.4 million 5-year Federal (NIH) R01 grant to study "Circadian clock and dietary restriction".
Dietary restriction is powerful intervention that delays the development of age-associated pathologies and increases lifespan in many organisms including humans. Dr. Kondratov's laboratory studies the molecular mechanisms of dietary restriction and its interaction with the circadian clock.

Sep. 14, 2011:
Congratulations to our newest GRHD member, Dr. Andrew Resnick, for receiving an NIH AREA award (R15) titled "Fluid flow may be an environmental modifier of ADPKD disease progression".
Research in his project will shed light on the autosomal dominant Polycystic Kidney Disease, which affects 1 in 1000 Americans, and for which no cure currently exists (

Aug. 24, 2011:
Congratulations to GRHD member Dr. Aimin Zhou for winning a two-year R15 Federal grant (NIH) to study "The role of RNase L in the pathogenesis of inflammatory bowel diseases".
Dr. Zhou is an expert in RNase L, an important player in our body's defence against viruses, inflammation, and cancer. In the recent past, three other GRHD members, Drs. Mazumder, Sun and Li, also won large NIH grants. Together, these highly competitive awards recognize and consolidate GRHD's overall mission to understand and cure human ailments through modern biomedical research.

Congratulations to GRHD member Dr. Bibo Li, recent recipient of a major NIH grant!!
Kudos and congratulations to our GRHD member, Dr. Bibo Li, for recently receiving a five-year NIH award totaling $1.8 million to continue her groundbreaking studies to understand how the Trypanosome parasite changes its surface proteins, which allows it to evade human immunity and cause African Trypanosomiasis, a fatal disease if left untreated. Dr. Li's success in this highly competitive field reflects the outstanding quality of research at GRHD. Of note, the 12 GRHD scientists, including Dr. Li, have collectively attracted roughly $11 million of external funding from various sources since 2000 to support cutting-edge biomedical research.

Two GRHD Members Receive $3 Million in Grants from National Institutes of Health
Posted on October 25, 2010

CSU Launches New Center for Advanced Biomedical Research
Posted on October 8, 2008

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Mailing Address
Center for Gene Regulation
in Health and Disease (GRHD)
2121 Euclid Avenue, SR 353
Cleveland, OH 44115-2214
Campus Location
2351 Euclid Avenue
Science and Research Bld., Room 353
Phone: 216-687-5580
Fax: 216.687.5549

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