The Cleveland Section of the American Chemical Society wishes to congratulate
Department of Chemistry and Biochemistry
The Ohio State University
The Morley address and medal will be presented on Wed. May 18 at the Michelson & Morley Restaurant on the campus of Case Western Reserve University.
2016 Morley Address:
Targeting Cancer with Transition Metal Complexes: From Basic Science to Therapy
The use of light to activate the action of a drug has become important as mode of cancer therapy, in some cases superior to traditional treatments, due to its low levels of invasiveness and systemic toxicity. Photoinduced ligand exchange, which can be used to release caged drugs or to induce covalent DNA binding with spatiotemporal control, together with the sensitization of
1O2, represent important reactions initiated by light with potential applications in photochemotherapy (PCT). These photoinduced reactions of Ru(II) and Rh2(II,II) complexes will be presented, along with their activity towards biological targets and cancer cells. Importantly, Ru(II) complexes were recently discovered to undergo multiple photochemical pathways following activation with light, and this property was used to design new dual-action compounds. These new complexes are able to both release a medically relevant compound and to produce 1O2 and were shown to exhibit significant enhancement of activity stemming from their ability to induce cell death via two different, independent pathways. New strategies developed for the photoinduced exchange of pyridine-containing drugs and their attachment to tumor-targeting antibodies will also be presented. These new complexes provide a new platform for drug delivery and enhanced therapeutic activity upon excitation with low energy light.
Click here for a brief bio of Prof. Turro
About the Morley Medal :
The Cleveland Section annually sponsors a regional award, which consists of the Morley Medal and an honorarium of $2,000. The next presentation of the Morley Medal will take place at the meeting of the Cleveland Section ACS in May 2016. The award is presented at a banquet, at which time the recipient will deliver the Edward W. Morley Lecture for that year. Travel expenses for the medalist and spouse will be provided.
The purpose of the award is to recognize significant contributions to chemistry through achievements in research, teaching, engineering, research administration and public service, outstanding service to humanity, or to industrial progress.
The area of eligibility includes those parts of the United States and Canada within about 250 miles of Cleveland. The contributions for which the award is given should have been made by the awardee when a resident of this area, or if a major contribution was made elsewhere, the nominee should have continued to make contributions while a resident of this area. Nominations may be made by any member of the American Chemical Society, The Chemical Society or the Chemical Institute of Canada.