2016 Morley Award winner is Claudia Turro of OSU
click here for more details
2016 Heller Award winner is Anne Lavelle
of St. Edward H.S.
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May Meeting Notice
Edward W. Morley Address and Award Presentation
Wednesday, May 18, 2016
Michelson and Morley Restaurant
Case Western Reserve University
5:00 – 5:45 Social/Networking - cash bar
5:45 – 7:00 Dinner
7:00 – 8:30 Morley Address and Award Presentation
Targeting Cancer with Transition Metal Complexes: From Basic Science to Therapy
Prof. Claudia Turro, The Ohio State University
The use of light to activate the action of a drug has become important as mode of cancer therapy, in some cases superior to traditional treatments, due to its low levels of invasiveness and systemic toxicity. Photoinduced ligand exchange, which can be used to release caged drugs or to induce covalent DNA binding with spatiotemporal control, together with the sensitization of 1O2, represent important reactions initiated by light with potential applications in photochemotherapy (PCT). These photoinduced reactions of Ru(II) and Rh2sub>(II,II) complexes will be presented, along with their activity towards biological targets and cancer cells. Importantly, Ru(II) complexes were recently discovered to undergo multiple photochemical pathways following activation with light, and this property was used to design new dual-action compounds. These new complexes are able to both release a medically relevant compound and to produce 1O2 and were shown to exhibit significant enhancement of activity stemming from their ability to induce cell death via two different, independent pathways. New strategies developed for the photoinduced exchange of pyridine-containing drugs and their attachment to tumor-targeting antibodies will also be presented. These new complexes provide a new platform for drug delivery and enhanced therapeutic activity upon excitation with low energy light.
The Social Hour and Dinner will be in the Michelson & Morley Restaurant in the Tinkham Veale University Center on the campus of Case Western Reserve University. Parking may be obtained in the Severance Hall garage, entrance off East Boulevard, and their is an entrance to the Tinkham Veale Center from the garage. (On street parking may also be available.)
Please indicate your dinner selection using the following link, http://goo.gl/forms/pcIgubDQGS.
The Award Presentation and Seminar will immediately follow dinner and be in the Thwing Center located next door to the Tinkham Veale University Center.
Questions may be addressed to firstname.lastname@example.org or by calling Mike Kenney, 440-488-3035
Important Update from the Cleveland Section
With support from an ACS grant we have begun a strategic planning exercise. Please click here for an article detailing the strategic planning retreat held Oct. 10-11, 2015